Standard dosage	10 mg daily to 40 mg daily
Contraindications	concomitant use with a monoamine oxidase inhibitor (MAOi), IV methylene blue, linezolid may lead to increased risk of serotonin syndrome
Main drug interactions	other medications that may prolong QTc interval, primarily metabolized by CYP2C19, 2D6, and 3A4. Weak inhibitor of 2D6.
Main side effects	diaphoresis, nausea, xerostomia, dizziness, headache, insomnia, somnolence, tremor, prolonged QTc interval, rare worsening depression
Special points	special consideration should be placed on risk of QTc prolongation, especially on 40 mg daily dose, strong caution against doses exceeding 20 mg in the elderly
Cost	inexpensive
Standard dosage	5 mg daily to 20 mg daily
Contraindications	concomitant use with a monoamine oxidase inhibitor (MAOi), IV methylene blue, linezolid may lead to increased risk of serotonin syndrome
Main drug interactions	metabolized by CYP2C19, 3A4
Main side effects	diaphoresis, diarrhea, nausea, headache, insomnia, somnolence
Special points	relatively selective SSRI and fewer drug interactions than others
Cost	relatively more expensive compared to other oral medications
Standard dosage	25 mg daily to 200 mg daily
Contraindications	concomitant use of disulfiram, concomitant use with a monoamine oxidase inhibitor (MAOi), IV methylene blue, linezolid may lead to increased risk of serotonin syndrome
Main drug interactions	metabolized by CYP450 2C19, inhibitor of 2D6, 3A4
Main side effects	diarrhea, indigestion, nausea, dizziness, headache, insomnia, somnolence, re- duced libido, fatigue, rash, hyponatremia
Special points	also has mild dopaminergic actions
Cost	inexpensive
Standard dosage	oral 12.5 mg daily to 400 mg a day divided by twice a day or three times a day
Contraindications	concomitant use with a monoamine oxidase inhibitor (MAOi), IV methylene blue, linezolid may lead to increased risk of serotonin syndrome, concomitant use with saquinavir/ritonavir
Main drug interactions	extensive CYP450 3A4 metabolism
Main side effects	nausea, headache, somnolence, blurred vision, fatigue, prolonged QT, rare seizures
Special points	has sedating properties and may be helpful for patients with insomnia or agitation, may cause worsening of cognition at higher doses
Cost	inexpensive