Table 4.

Hazard ratio (95% confidence interval) of incident stroke according to baseline 25-hydoxyvitamin D (25(OH)D) categories stratified by stroke subtype.

	25(OH)D > 30 ng/ml	25(OH)D 20 – 30 ng/ml	25(OH)D < 20 ng/ml	P trend
Restricted to all ischemic strokes (n=536)
Events	150	183	203	536
Model 1*	ref	1.03 (0.77, 1.37)	1.59 (1.15, 2.19)	0.004
Model 2†	ref	1.18 (0.83, 1.66)	1.59 (1.09, 2.34)	0.02
Model 3‡	ref	1.27 (0.85, 1.91)	1.84 (1.14, 2.97)	0.01
Restricted to cardioembolic ischemic strokes (n=134)
Events	45	44	45	134
Model 1*	ref	0.84 (0.53, 1.33)	1.34 (0.79, 2.27)	0.43
Restricted to large vessel disease ischemic strokes (n=84)
Events	28	31	25	84
Model 1*	ref	1.09 (0.62, 1.94)	1.64 (0.89,3.01)	0.13
Restricted to small vessel disease ischemic strokes (n=104)
Events	43	37	24	104
Model 1*	ref	1.42 (0.82, 2.47)	2.03 (1.11, 3.70)	0.02
Restricted to unclassified ischemic strokes (n=244)
Events	99	78	67	244
Model 1*	ref	0.96 (0.66, 1.39)	1.67 (1.11, 2.52)	0.02
Restricted to all hemorrhagic strokes (n=74)
Events	17	30	27	74
Model 1*	ref	1.48 (0.78, 2.81)	1.82 (0.91, 3.65)	0.08
Restricted to intra-cerebral hemorrhagic strokes (n=61)
Events	13	27	21	61
Model 1*	Ref	1.79 (0.89, 3.63)	2.09 (0.96, 4.56)	0.05
Restricted to sub-arachnoid hemorrhagic strokes (n=13)
Events	4	3	6	13
Model 1*	ref	0.53 (0.11, 2.53)	0.96 (0.24, 3.79)	0.99

^*Adjusted for age, race, age*race interaction and sex

^†Adjusted for age, race, age*race interaction, sex, season of blood draw, systolic blood pressure, body mass index, diabetes, left ventricular hypertrophy, current smoking, atrial fibrillation, coronary heart disease, estimated glomerular filtration rate, log-transformed albumin to creatinine ratio and use of anti-hypertensive medications, statins, and aspirin.

^‡Adjusted for terms in Model 2 + serum calcium, phosphorus, intact parathyroid hormone, high-density lipoprotein, low-density lipoprotein, total cholesterol and triglyceride concentrations.