Figure 5.

Summary of significant results from RNAi proteostasis screen. Late L4 developmental stage P_mec-4GFP animals (strain ZB4064) were cultured at 25 ° from hatching, treated with neuron-targeted RNAi at the late L4 stage, and assessed for neuronal morphology integrity on day 5 of adulthood. Enhancers or suppressors in outer ring refer to previously published reports of enhancement or suppression of polyQ or other protein aggregation toxicity, disaggregation and/or protein toxicity.^17,21–40 GFP, green fluorescent protein; RNAi, RNA interference.