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. Author manuscript; available in PMC: 2016 Jun 24.
Published in final edited form as: J Alzheimers Dis. 2015;45(2):509–520. doi: 10.3233/JAD-142304

Fig. 2.

Fig. 2

Insulin receptor autophosphorylation is reduced by partial loss of GLT-1 and AβPP/PS1 at 6 months of age. A, B) Western blots from 6 and 9 month animals, respectively. C, D) Indicating reduced insulin receptor activation, densitometric quantification of blots in (A) and (B) revealed a statistically significant decrease (p ≤ 0.039) in the ratio of Tyr1150/1151 phosphorylated IRβ to total IRβ in GLThet and AβPP/PS1 transgene mice compared to GLT-1wt/nTg mice at 6 (C), but not at 9 (D) months of age. Each lane represents one animal. Data are presented as normalized means ± SEM (n = 6 mice per group).