Table 3.
Potential allopeptides presented by HLA-B*35;01 after infection with VACV
| Gene | Variants | VACVc | ||
|---|---|---|---|---|
| Aa | Bb | Cb | ||
| PABPC1 | VPNPVINPY | VPHPVINPY | ||
| CNOT8 | FPSIYDVKY | SPSIYDVKY | FPVIYDVKY | |
| UPP1 | FPALFGDVKF | FPALFGDVKV | LPAMFGDVKF | |
| LOC441837 | DPFIDLNYM | DPFIDLKYM | ||
| LOC387820 | SPEDIKKAY | SPEEIKKAY | ||
| ACTB | APEEHPVLL | APEEHPILL | ||
| CNOT7 | FPVIYDVKY | FPSIYDVKY | ||
| USP11 | TPARDYNNSY | TPARDYSNSS | ||
| UBE2D2 | YPFKPPKVAF | YPFKPPKVTF | ||
| C1D | YPVEIHEYL | YPVEIHDYL | ||
| ADAR | NPISGLLEY | NPVSGLLEY | ||
| DDX50 | SPPQDVESY | SPPQDIESY | ||
| ITM2B | DPANIVHDF | DPADIIHDF | ||
| DDOST | FPDKPITQY | FPDKPITQV | FPDKRITQY | |
| KIAA0828 | GPFKPNYYRY | GPFKPDHYRY | ||
| CCND1 | TPHDFIEHF | TPHDFIEHI | ||
| HNRPD | TPEEKIREYF | ATEEKIREYF | ||
| MLSTD2 | NPFHWGEVEY | NPFHWGEVGM | ||
| THRAP1 | KPINKSEHL | KPVNKSEHL | ||
| EFHD2 | NPYTEFKEF | NPYTEFPEF | ||
| CCT6A | HPRIITEGF | HPRIIAEGF | ||
| BACH1 | SPEPGQRTF | *PEPGQRTF | ||
| HSPA4L | APFSKVITF | APFSKVLTF | ||
| NIT2 | IPEEDAGKLY | IPEEDAGKLD | ||
| RPL15 | RPVPKGATY | HPVPKGATY | RPVPKGVTY | |
| OTUB1 | FPEGSEPKVY | FPEGSEPQVY | ||
| ROR2 | FPELGGGHAY | FPELNGGHSY | ||
| ARGBP2 | FPISYVEKL | FPISYVEKP | ||
| MYO1G | DPIGGHIHSY | DPIGGHINNY | ||
| DEK | FPFEKGSVQY | FPFEKGSAQY | ||
| UBE2E1 | YPFKPPKVTF | YPFKPPKITF | ||
| KIF1A | IPQLCEDLF | IPQLCEELF | ||
| TUBB3 | YPDRIMNTF | YPDRIINTF | ||
| CTNNA1 | NPVQALSEF | SPVQALSEF | ||
| SF3B4 | RPITVSYAF | HPITVSYAF | ||
| ATP6V1B2 | HPIPDLTGY | HPIPDLTGF | ||
| C20orf172 | HPIHQGITEL | HPIHQGITEV | ||
| ADAR | NPVGGLLEY | NPVSGLLEY | ||
| MTHFD1 | TPVPGGVGPM | TPVSGGVGPM | ||
| SMARCA2 | APSVVKISY | APSVVKVSY | ||
| KIAA1374 | TPYPAILHEY | PPYPAILHEY | ||
| SPTBN1 | YPNVNIHNF | YPNVNVHNF | ||
| KIAA1102 | SPLGGERPF | SPLGGQRPF | ||
| UBAP2 | NPYPGDVTKF | NPYSGDVTKF | ||
| SMARCA5 | APFHQLRISY | APFHQLRIQY | ||
| NT5C | FPEEPHVPL | SPEEPHVPL | ||
| DIAPH1 | NPVSWVQTF | NPVSWVESF | ||
| CTPS | RPIKPSPPY | RPMKPSPPY | ||
| HSPA8 | IPTKQTQTF | IPTKQTQIF | TQ6NF K4R;Q5K;Q7R |
|
| SUHW2 | NPIVLLSDF | NPIVLLSNF | ||
| CP | FPRTPGIWL | FPRTPGLWL | ||
| MYO1C | APVGGHILSY | IPVGGHIISY | ||
| UBP1 | SPWPDAPTAY | SPWPDASTAY | ||
| DHX38 | TPLPTPSYKY | TPLPAPSYKY | ||
| LPP | YPVTGPKKTY | CPVTSPKKTY | ||
| FLJ10706 | LPLWQHISF | SPLWQHIGF | ||
| FHL2 | KPITTGGVTY | MPITTGGVTY | ||
| TTF1 | FPFRDIFYY | FPSRDIFYY | ||
| UBE2D1 | YPFKPPKIAF | YPFKPPKITF | ||
| C6orf150 | VPRIQLEEY | VPRIQLEDF | ||
| HDHD4 | KPAPSIFYY | LPAPSIFYY | ||
| KIF21A | HPNNVVSVKY | HPNNVVSIKY | ||
| LOC441032 | HPGQISAGY | HPGQISSGY | ||
| AHCY | GPFKPDHYRY | CPFKPDHYRY | ||
| FLJ14827 | APHTNGPQDL | VPHTNGPQDL | ||
| BNIP2 | MPESSQPNY | TPESSQPNY | ||
| UBE2V2 | LPQPPEGQTY | LPQPPEGQCY | ||
| TUSC4 | HPTLGPKITY | HLTLGPKITY | ||
| NME2 | RPFFPGLVKY | RPFFAGLVKY | ||
| TCP1 | HPTSVISGY | HPTSVISSY | ||
| FLNB | IPYLPITNF | VPYLPITNF | ||
| LOC220717 | VPHSIINGY | VPHSIIDGY | ||
| PSMC4 | LPLTHFELY | LPVTHFELY | ||
| ZNF581 | SPCPQPLAF | SPCPQPLPF | ||
| TFCP2L2 | LPLNIQVDTY | LPLNIQIDTY | ||
| TOP2A | LPVKGFRSY | LPVNGFRSY | ||
| PHCA | YPWLRGLGY | YPWLRGLGI | ||
| ASCC3L1 | RPVPLEQTY | RPVPLERTY | ||
| SLC25A6 | IPKEQGVLS F | IPKDQGVLSF | ||
| LOC391387 | HPWKVMPDL | HPWEVMPDL | ||
| LOC339077 | LPKLEKAARL | LPKLERAARL | ||
| HSPA8 | QPGVLIQVY | QPGVFIQVY | ||
| SUHW1 | NPIVLLSNF | NPIVLLSDF | ||
| VIL2 | FPWSEIRNI | FPWNEIRNI | ||
| ING1 | LPIDPNEPTY | MPVDPNEPTY | ||
| FLJ14803 | HPKYPDGKTF | HPKYRDGKTF | ||
| LOC391387 | HPWKVMPDLY | HPWEVMPDLY | ||
| GAPD | APSADAPMF | TPSADAPMF | ||
| CARD8 | HPHPEDIKF | RPHPEDIKF | HRHPEDIKF | |
| NACA | SPASDTYIVF | SPASDTYVVF | ||
| TPMT | DPTKHPGPPF | DPTKHAGPPF | ||
| LOC391062 | RPNSNGSQFF | PNTNGSQFF | ||
| ANXA7 | YPQPPSQSY | YPQPPSQSI | ||
| RYR1 | SPHEQEIKFF | SPRDQEIKFF | ||
| ADIPOR2 | APLQEKVVF | PPLQEKVVF | ||
| FLJ10774 | IPWTVSEQF | IPWTVSEQV | ||
| ALB | VPQVSTPTL | VPEVSTPTL | ||
| TIP120A | GPLVSKVKEY | GPLVVKVKEY | ||
| PTPRS | WPDHGVPEY | WPDHGVPEH | ||
| GRK5 | KPENILLDDY | KPENILLDDH | E3D;D8F;Y10S | |
| ENO1 | SPDQLADLY | SPNQLADLY | ||
| ARHGEF1 | VPVPPNVAF | PPVPPNVAF | ||
| SORCS3 | SPVHCLLPF | SPVHCLLPQ | DPVHCLLPY | |
| MAGI 1 | KPGEGLGMY | KPSEGLGMY | ||
| ITGB4 | RPLQGYSVEY | RPLQGYSVAS | ||
| HLA-C | HPLSDHEATL | HPISDHEATL | ||
| SLC17A6 | MPLAGILVQY | MPLAGVLVQY | ||
| UBE2L3 | YPFKPPKITF | YPFKPPKVTF | ||
| PIK3C2B | LPQLVQALKY | LSQLVQALKY | ||
| CDC42 | FPSEYVPTVF | FPGEYVPTVF | ||
| ProSAPi P1 | DPGRDPLLAF | DPGKEPLLAF | ||
| AATF | LPQPDVFPLF | LPQPDVFPVF | ||
| RER1 | LPTKQNEEF | YPTKQNEEF | LPTIQNEEF | |
| GRK5 | SPDYWGLGCL | SPDWWGLGCL | ||
| PACS2 | LPIAEAMLTY | LPVAEAMLT | ||
| NDUFB9 | FPDSPGGTSY | FPDSPRGTSY | ||
| LIPC | QPGCHFLELY | QPGCHSLELY | ||
| HNRPK | FPNTETNGEF | FPNTETSGEF | ||
| DHRS4 | SPSPGFSPY | IPSPGFSPY | ||
| METAP2 | FPKGQECEY | FPKGQESEY | ||
| SMOC1 | RPLPGTSTRY | RPIPGTSTRY | ||
| DHX40 | MPDHVIPEI | MPDHVIPQF | ||
| PREI3 | TPKECPAIDY | TPKECRAIDY | ||
| PCDHB5 | APETVVAVF | SPETVVAVF | ||
| SMARCE1 | MPSTPGFVGY | MPSTPSFVGC | ||
| DSC3 | IPCSMQENSL | IPCSMLENSL | ||
| RHOC | FPEVYVPTVF | FPEEYVPTVF | ||
| NOTCH1 | CPPGFTGSY | CPPGFTGDY | ||
| GLCCI1 | CPDKNKVNF | CPDKNKVHF | ||
| BIRC5 | DPIGPGTVAY | DPIGPGTVA | ||
| SMURF2 | NPYYGLFQY | NPYYGLFEY | ||
| MEN1 | APDPPGGLTY | APDPHGGLTY | ||
| NUP210L | SPLTPGLAIY | KSLTPGLAIY | ||
| ING5 | MPVDPNEPTY | LPIDPNEPTY | ||
| JUP | SPVESVLFY | SPVDSVLFY | ||
| UBE2D2 | SPYQGGVFF | RPYQGGVFF | ||
| GPNMB | GPQLMEVTVY | GPQFMEVTVY | ||
| PURB | LPAQGLIEF | LPAQGMIEF | ||
| CPA4 | LPVANPDGY | LPVTNPDGY | ||
| LOC440059 | CPIMDLTLY | CPIMDLTL | ||
| CDADC1 | LPDANTDFY | LPDANTDLY | ||
| TINP1 | TPQGAVPAY | IPQGAVPAY | ||
| IFI16 | MPPSTPSSSF | MPPTTPSSSF | ||
| AATF | LPQPDVFPL | LPQPDVFPVF | ||
| FMNL3 | DPSVTRKKF | DPAVTRKKF | ||
| B4GALT6 | APGIANTYLF | APGIVNTYLF | ||
| GPR | VPVVVVFLFL | IPVVVIFLFL | ||
| ATXN10 | HPDKKIVAY | CPDKKIVAY | ||
*
Indicates corresponding amino acid is deleted in variant
a
Peptide sequence identified by mass spectrometry
b
Alternate peptide sequences identified by BLAST search
c
Amino acid substitutions compared with VACV proteome. Only amino acid substitutions from sequences >66% identical are annotated. Blank, no significant homology.