Table 4. Binding of Key Compounds to PB1(5) Was Assessed by Isothermal Calorimetry.
compd | K × 106 (M–1) | KD (nM) | ΔH (kcal/mol) | TΔS (kcal/mol) |
---|---|---|---|---|
18 | 7.29 ± 0.91 | 137 (157–122) | –6.2 | 3.0 |
24 | 7.86 ± 0.89 | 127 (143–114) | –5.2 | 4.0 |
26 | 8.09 ± 0.66 | 124 (135–114) | –5.0 | 4.3 |
27 | 7.05 ± 0.68 | 142 (157–129) | –4.4 | 4.7 |
28 | 5.88 ± 0.60 | 170 (189–154) | –6.8 | 2.3 |