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. 2016 Jun 1;9(6):697–705. doi: 10.1242/dmm.022665

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — IFM mutants are susceptible to bacterial infection. (A) Hematoxylin-stained hemithoraces of the fly strains used in the study, alongside a representative schematic, show a spectrum of defects in the IFMs. CS: the wild-type fly strain Canton-S. (B,C) Survival curves of the muscle mutants post-infection with (B) Salmonella and (C) Bacillus subtilis by septic injury. A log-rank test was done for estimating the significance of the survival curves. (B) Salmonella infected versus uninfected: Canton-S, P=0.0094; up¹, P=0.0034; up¹⁰¹, P<0.0001; hdp², P<0.0001; hdp³, P<0.0001; TM2³, P=0.0006; Act88F^KM88, P<0.0001. Mutant versus wild type: up¹, P=0.1171; up¹⁰¹, P<0.0001; hdp², P<0.0001; hdp³, P<0.0001; TM2³, P=0.0364; Act88F^KM88, P<0.0001. (C) Bacillus infected versus uninfected: All fly strains, P<0.0001. Mutant versus wild type: up¹, P=0.0139; up¹⁰¹, P=0.0002; hdp², P=0.0346; hdp³, <0.0001; TM2³, P=0.1646; Act88F^KM88, P=0.0009. n>80. Open circles, IFM-specific mutants; dashed lines, uninfected controls; U, uninfected; I, infected; dpi, days post-infection; hpi, hours post-infection.