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. 2016 Jun 1;9(6):633–645. doi: 10.1242/dmm.024455

Fig. 5.

Fig. 5.

Crotonate increases PGC-1α and SIRT3 mRNA and decreases CCL2 mRNA expression in mouse kidney. Mice were treated with 12 mmol/kg body weight crotonate for different times. (A,B) Crotonate increases kidney PGC1α expression at mRNA levels as assessed by qRT-PCR (A) and at the protein level by western blotting (B). Mean±s.e.m. of four per group. *P<0.05 vs control (non-parametric Mann–Whitney U-test). (C) Crotonate decreases whole kidney CCL2 mRNA levels as assessed by qRT-PCR. Mean±s.e.m. of four per group. *P<0.05 vs control (non-parametric Mann–Whitney U-test). (D,E) Crotonate increases whole kidney SIRT3 mRNA levels as assessed by qRT-PCR (D) and the SIRT3 protein level as assessed by western blotting (E). Mean±s.e.m. of four per group. *P<0.05 vs control (non-parametric Mann–Whitney U-test).