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. 2016 Jun 1;143(11):1914–1925. doi: 10.1242/dev.131664

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Model for context-specific Wnt/β-catenin target gene regulation. (A) In the previous concept established from studies of individual genes, Wnt signalling specifically controls β-catenin recruitment to the Wnt-response element (WRE) of context-specific target genes and leads to their transcription (e.g. gene B in the context-X). (B) In the revised concept from our studies, Wnt-regulated β-catenin recruitment takes place at numerous loci. Transcriptional activation at those loci is conditional on context-specific mechanisms (e.g. a context-X-specific mechanism for gene B in context-X).