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. 2016 May 11;5(6):709–719. doi: 10.1242/bio.016477

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Many retinal disease-related genes were induced in CRX-transduced PBMCs prepared by SeV. Expression of retinal disease-related genes in CRX-transduced and control (non-transduced) PBMCs by RT-PCR. Results of PDE6H, CNGA1, RPGRIP1, C2orf71, CC2D2A, COPTF1 and TSPAN12 are from No. 1 PBMCs sample, those of RBP4, GUCA1A, GUCA1B, GUCY2D, PDE6A, SAG and GPR98 are from No. 2 sample, and those of RP1L1, MAK, NPHP1, TLR3, RDH12, TUB and FZD4 are from No. 3 sample. PBMCs transduced with CRX via SeV vectors more efficiently induced retinal disease-related genes than those transduced with CRX via retrovirus vectors, and most of the detected genes were related to photoreceptor functions. CS/ECM, cytoplasm/extracellular matrix; OS, outer segment; C, cilia-related; IS, inner segment; ONL, outer nuclear layer; TF, transcription factor.