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The role of Pkaap in the regulation of antimicrobial peptide exocytosis in fat body cells. (A) Schematic representation of the nucleotide-dependent location of Pkaap to recycling endosomes. Pkaap binds to GTP-bound constitutively active form of Rab4 and GDP-bound dominant negative form of Rab11. (B) Schematic diagram showing the role of Pkaap in the regulation of membrane trafficking by modulating Rab4 and Rab11 activities. GTP, guanosine triphosphate; GDP, guanosine diphosphate.
