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. 2016 May 16;5(6):794–800. doi: 10.1242/bio.017798

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Silencing of leptin by leptin-targeted siRNA induced apoptosis in NSCLC A549 and 95D cells. (A,D) Flow cytometry analysis was used to detect the apoptosis in A549 and 95D cells after siRNA transfection. (B,E) The apoptosis rate in A549 and 95D cells. Cells transfected with leptin siRNA presented more apoptosis compared with the cells transfected with control siRNA. (C,F) Expression levels of Bcl-2 and Bax in A549 and 95D cells after siRNA transfection. Leptin RNAi significantly decreased Bcl-2 expression and increased Bax expression in both the NSCLC cell lines. Data expressed as mean± s.e.m.; **P<0.01 compared to control siRNA-treated cells.