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. 2016 May 16;5(6):794–800. doi: 10.1242/bio.017798

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Notch-1 siRNA inhibited cell proliferation and induced apoptosis in A549 cells. (A) MTT assay showed that the growth rate of the Notch-1 siRNA-treated cells was significantly lower than the control siRNA-treated cells after transfection for 48 h (B) Flow cytometry analysis revealed that Notch-1 siRNA significantly induced apoptosis in A549 cells. (C) The expression levels of Ki67 and Bcl-2 were markedly downregulated and Bax expression was upregulated in Notch-1 siRNA-treated cells compared with control siRNA-treated cells. Data expressed as mean± s.e.m.; *P<0.05 and **P<0.01 compared to control siRNA-treated cells.