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. 2016 May 16;5(6):794–800. doi: 10.1242/bio.017798

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Inactivation of JAK/STAT3 signaling pathway suppressed cell viability and induced apoptosis in A549 cells. Cells were treated with 1 μM JAK/STAT3signaling pathway inhibitor, JSI-124 for 12 h. (A) Cell proliferation was measured by MTT assay. JSI-124 treatment significantly inhibited the growth of A549 cells compared with control group. (B) Flow cytometry analysis was used to detect the apoptosis in A549 after JSI-124 treatment. (C) The expression levels of Ki67 and Bcl-2 were markedly downregulated and Bax expression was upregulated in JSI-124-treated cells compared with control group. Data expressed as mean±s.e.m.; *P<0.05 and **P<0.01 compared to control group.