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. 2015 Jul 22;4:297. [Version 1] doi: 10.12688/f1000research.6789.1

Figure 4. Proton extrusion through VGSC and NHE-1 (sodium hydrogen exchanger-1) produces acidification of extracellular matrix surrounding the cellular membrane (yellow area in the figure).

Figure 4.

(Brisson 2013 39; Gillet 2009 40). Acidification activates cathepsine degradation of the extracellular matrix.