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Explanted cardiac muscle from a 14-year-old male with Danon disease. Images show (A) a cross-section of explanted heart with biventricular hypertrophy and fibrosis, (B) a photomicrograph (with trichrome stain) of cardiomyocytes (red) and extensive fibrosis (blue) and (C) a photomicrograph (with hematoxylin and eosin stain) revealing extensive vacuolization. Scale bars: 100 μm. Reprinted from Taylor et al. (2007) with permission. Copyright 2007, Nature Publishing Group.
