Fig. 2.

Amino acid sequence alignments of the LAMP-2A and LAMP-2B isoforms in human and mouse. Alignments show (A) human and mouse LAMP-2 (exons 1–8), (B) human and mouse LAMP-2A and LAMP-2B isoforms (exon 9 only), which are the LAMP-2 isoforms most relevant to Danon disease, and (C) human LAMP-2A and LAMP-2B isoforms (exon 9 only). Blue and yellow backgrounds indicate identical and similar amino acids, respectively. Gray backgrounds indicate cysteine residues thought to be involved in disulfide bridges. Black, red and green font colors indicate lumenal, transmembrane and cytoplasmic residues, respectively (Eskelinen et al., 2005). Amino acid sequences were obtained from Ensembl, and alignments were generated using the Bioinformatics Organization Multiple Align Show tool.