Fig. 6.

Schematic diagram of a model for interaction between kinesin-12 and myosin-IIB during astrocyte migration. Kinesin-12 is a microtubule-based plus-end-directed motor, and myosin IIB, a non-muscle myosin-II heavy chain, is an actin-dependent molecular motor. In the lamellar region of astrocytes, kinesin-12 directly interacts with myosin-IIB through their tail domains. We posit that the two motors form a hetero-oligomer that generates force to integrate microtubules and actin filaments during the migration of astrocytes.