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. 2016 May 13;5:141–149. doi: 10.1016/j.bonr.2016.05.002

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Femoral bone: Structural features of cortical bone. Structural features were assessed in the cortical ROI by micro-CT as described in the Materials and Methods. Data are based on 5 mice at baseline (4 weeks of age), 10 mice at the 5 and 12 month time-points and 15 mice at the 18 month time-point in each group. Values are means and standard deviations. Statistical significance of each parameter was assessed by ANOVA followed by paired group comparisons. Statistical significance at the p < 0.05 level is indicated by the letters “a”, “b”, and “c”. The letter “a” above the HFWD + AQ bar indicates statistically significant improvement relative to HFWD alone. The letter “b” above the HFWD + AQ bar indicates statistically significant improvement relative to AIN76A group. The letter “c” above the AIN76A + AQ bar indicates statistically significant improvement relative to AIN76A alone. All of the cortical micro-CT parameters measured at the three time points are presented in Supplement Table 4. Insert: Representative 3D micro-CT images of the cortical ROI from the femora of mice in each diet group, at each time-point.

Femoral bone: Structural features of cortical bone. Structural features were assessed in the cortical ROI by micro-CT as described in the Materials and Methods. Data are based on 5 mice at baseline (4 weeks of age), 10 mice at the 5 and 12 month time-points and 15 mice at the 18 month time-point in each group. Values are means and standard deviations. Statistical significance of each parameter was assessed by ANOVA followed by paired group comparisons. Statistical significance at the p < 0.05 level is indicated by the letters “a”, “b”, and “c”. The letter “a” above the HFWD + AQ bar indicates statistically significant improvement relative to HFWD alone. The letter “b” above the HFWD + AQ bar indicates statistically significant improvement relative to AIN76A group. The letter “c” above the AIN76A + AQ bar indicates statistically significant improvement relative to AIN76A alone. All of the cortical micro-CT parameters measured at the three time points are presented in Supplement Table 4. Insert: Representative 3D micro-CT images of the cortical ROI from the femora of mice in each diet group, at each time-point.