(A-C) Non-fasting blood glucose levels in STZ- and vehicle-treated C57BL/6 (A) and C3H/HeN (B) mice, and in Akita mice and age-matched wild type C57BL/6 mice (C). (D-F) Body weight of STZ- and vehicle-treated C57BL/6 (D) and C3H/HeN (E) mice, and of Akita mice and age-matched wild type C57BL/6 mice (F). T0 stands for baseline values (before STZ treatment), Ti corresponds to time of infection, and Tf stands for time of sacrifice. N = 17–21 mice per group. Statistical analysis: (A-B, D-E) Two-way ANOVA with Holm-Sidak post-tests. (C, F) Two-tailed t-test. * indicates p<0.05 vs. T0 within group; † indicates p<0.05 vs. Vehicle within time point. ^ indicates p<0.05 vs wild-type.