Table 3. Mutation frequencies estimated by the Separate method.

Mutation type	Mutation frequency	Mutation type	Mutation frequency	p-value
A>C	8.3x10-7	T>G	1.3x10-6	0.80
C>G	3.1x10-6	G>C	2.5x10-6	0.30
A>T	2.3x10-6	T>A	3.5x10-6	0.87
A>G	6.7x10-6	T>C	6.5x10-6	0.47
C>T (non-CpG)	3.7x10-5	G>A (non-CpG)	2.8x10-5	0.01
G>T	4.7x10-5	C>A	3.7x10-5	0.02
C>T (CpG)	3.3x10-4	G>A (CpG)	1.6x10-4	0.0001

Data from the PTPN11 experiment.