Fig 3. DENV2 challenge of 5-week old mice born to and/or nursed by DENV1-immune mothers.

DD, DN, ND and NN groups were iv. infected with 10⁶ PFU DENV2. (A) Survival rate, (B) clinical score of individual group (0: Healthy; 1: Ruffled fur; 2: Hunched back; 3: Diarrhoea; 4: Lethargic; 5: Moribund) (n = 8) and (C) viremia measured at day 4 post-infection (n = 5). Dotted line denotes the limit of detection in plaque assay. *p<0.05; **p<0.01 based on Mann-Whitney test compared against NN control.