Table 1. Morbidity and average survival time (AST) of mice, infected with control and chimaeric TBEV during the feeding of female I. ricinus.

	Morbidity,%	Significance,p =	AST, days
Vs IC	86	0.13**	15
Vs[Hypr E]	35	0.0001*	10
Vs[Hypr PrM-E]	75	0.55*	20
Vs[Hypr str]	100	0.13*	14
Hypr IC	100	0.13*	9
Hypr IC[short 3`UTR]	87,5	0.29**	>21
Hypr[Vs E]	75	0.1**	>21
Hypr[Vs PrM-E]	100	1**	20
Hypr[Vs str]	29	0.0001**	9

*—significance of the differences in comparison to wild-type VsIC virus was determined by single sample Student’s t-test for proportions

**—significance of the differences in comparison to wild-type HyprIC virus was determined by single sample Student’s t-test for proportions