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. 2016 Jun 24;11(6):e0157969. doi: 10.1371/journal.pone.0157969

Table 4. Univariable and multivariable analyses for progression-free survival.

Univariable analysis Multivariable analysisa
HR 95% CI P HR 95% CI P
Age 0.992 0.963–1.022 0.606 ND
Sex (male as reference) 0.899 0.368–2.194 0.815 ND
T-classification
T1/T2 vs. T3/T4 0.357 0.168–0.759 0.007 0.363 0.170–0.761 0.009
N-classification
N0/N1 vs. N2/N3 0.708 0.347–1.446 0.343 ND
Overall stage
I/II vs. III/IVA-B 0.437 0.179–1.066 0.069 0.456 0.176–1.131 0.110
IMRT alone 2.632 0.628–10.989 0.186 ND
Concurrent chemoradiation 0.643 0.225–1.838 0.410 ND
Induction chemotherapy then concurrent chemoradiation 0.335 0.160–0.702 0.014 0.401 0.205–1.563 0.254
Concurrent chemoradiation then adjuvant chemotherapy 0.820 0.404–1.664 0.582 ND
PD-L1 expression level
PD-L1 1+ 0.386 0.135–1.104 0.076 0.398 0.140–1.108 0.056
PD-L1 2+ 0.346 0.105–1.010 0.067 0.351 0.108–0.999 0.045

Abbreviations: CI, confidence interval; HR, hazard ratio; IMRT, intensity-modulated radiation therapy; ND, not done; PD-L1, programmed death-ligand 1.

aOnly covariates found significant (P < 0.1) in the univariable analysis were considered in the multivariable analysis.