Table 4. Univariable and multivariable analyses for progression-free survival.
Univariable analysis | Multivariable analysisa | |||||
---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | |
Age | 0.992 | 0.963–1.022 | 0.606 | ND | ||
Sex (male as reference) | 0.899 | 0.368–2.194 | 0.815 | ND | ||
T-classification | ||||||
T1/T2 vs. T3/T4 | 0.357 | 0.168–0.759 | 0.007 | 0.363 | 0.170–0.761 | 0.009 |
N-classification | ||||||
N0/N1 vs. N2/N3 | 0.708 | 0.347–1.446 | 0.343 | ND | ||
Overall stage | ||||||
I/II vs. III/IVA-B | 0.437 | 0.179–1.066 | 0.069 | 0.456 | 0.176–1.131 | 0.110 |
IMRT alone | 2.632 | 0.628–10.989 | 0.186 | ND | ||
Concurrent chemoradiation | 0.643 | 0.225–1.838 | 0.410 | ND | ||
Induction chemotherapy then concurrent chemoradiation | 0.335 | 0.160–0.702 | 0.014 | 0.401 | 0.205–1.563 | 0.254 |
Concurrent chemoradiation then adjuvant chemotherapy | 0.820 | 0.404–1.664 | 0.582 | ND | ||
PD-L1 expression level | ||||||
PD-L1 1+ | 0.386 | 0.135–1.104 | 0.076 | 0.398 | 0.140–1.108 | 0.056 |
PD-L1 2+ | 0.346 | 0.105–1.010 | 0.067 | 0.351 | 0.108–0.999 | 0.045 |
Abbreviations: CI, confidence interval; HR, hazard ratio; IMRT, intensity-modulated radiation therapy; ND, not done; PD-L1, programmed death-ligand 1.
aOnly covariates found significant (P < 0.1) in the univariable analysis were considered in the multivariable analysis.