Table 3. Top ten genes from the G_up-positive and G_{down-negative} groups associated with survival outcomes in ordinary-luminal patients.

Group	Gene symbol	Gene name	pSurvival	pDifference
Gup-positive	POLQ	polymerase (DNA directed), theta	4.6 ⋅ 10−6	1.5 ⋅ 10−72
	CKAP2L	cytoskeleton associated protein 2 like	6.1 ⋅ 10−6	8.8 ⋅ 10−70
	KIFC1	kinesin family member C1	6.2 ⋅ 10−8	3.4 ⋅ 10−69
	FOXM1	forkhead box M1	3.5 ⋅ 10−8	2.1 ⋅ 10−68
	TROAP	trophinin associated protein	9.8 ⋅ 10−6	8.7 ⋅ 10−67
	UBE2C	ubiquitin conjugating enzyme E2C	1.3 ⋅ 10−6	1.7 ⋅ 10−66
	AURKB	aurora kinase B	6.5 ⋅ 10−5	2.1 ⋅ 10−66
	NCAPG	non-SMC condensin I complex subunit G	1.1 ⋅ 10−6	3.3 ⋅ 10−66
	HJURP	Holliday junction recognition protein	1.4 ⋅ 10−5	5.9 ⋅ 10−66
	MCM10	minichromosome maintenance 10 replication initiation factor	2.7 ⋅ 10−4	1.1 ⋅ 10−64
Gdown-negative	PLSCR4	phospholipid scramblase 4	3.1 ⋅ 10−5	5 ⋅ 10−49
	GSN	gelsolin	3.8 ⋅ 10−4	2.4 ⋅ 10−48
	OGN	osteoglycin	2 ⋅ 10−4	2.2 ⋅ 10−43
	MAMDC2	MAM domain containing 2	4 ⋅ 10−3	2.6 ⋅ 10−43
	DIXDC1	DIX domain containing 1	1.2 ⋅ 10−4	1.4 ⋅ 10−41
	CH25H	cholesterol 25-hydroxylase	5.9 ⋅ 10−4	3.1 ⋅ 10−40
	MIR99AHG (C21orf34)	mir-99a-let-7c cluster host gene	3.9 ⋅ 10−4	1.2 ⋅ 10−39
	CDC14B	cell division cycle 14B	1 ⋅ 10−4	8.7 ⋅ 10−38
	SPRY2	sprouty RTK signaling antagonist 2	1.6 ⋅ 10−3	1.2 ⋅ 10−36
	ANKRD35	ankyrin repeat domain 35	2.6 ⋅ 10−4	6.5 ⋅ 10−36

The top ten genes representing each of the groups G_up-positive and G_{down-negative}, associated with variations in survival outcomes in ordinary-luminal breast cancer patients in the METABRIC training set, are listed in the second column. G_up-positive genes are up-regulated in luminal tumours when compared to controls, and their over-expression is also associated with worse prognosis. G_{down-negative} are down-regulated relative to controls, and their decreased levels are correlated to lower survival rates. The Log-rank test p-values (p_Survival) reflect the survival stratification power of each single probe based on two groups of patients of the same size (section Survival Filter). P-values in the last column (p_Difference) were calculated using the Wilcoxon test, representing probes separation power between the clusters of luminal samples defined in section Defining a Molecular Signature of Patients at Risk.