Table 1.

Selectivity profile of 5-HT_2A/2C drugs used in the studyⁱ.

Compound	5-HT2A			5-HT2B			5-HT2c			2C/2A
Ki (nM) a	pEC50b	Efficacy c	Ki (nM)	pEC50	Efficacy	Ki (nM)	pEC50	Efficacy
5-HT2ARs
TCB-2d	0.73	6.8	–	–	–	–	–	–	–	–
MDL11,939e	2.8	–	–	1419	–	–	853	–	–	–
M100,907f	1.9e	8.9	–	261e	6	–	88e	7.7	–	0.06
5-HT2CRs
CP-809,101g	6	6.8	0.67	64	7.2	0.57	1.6	10	0.93	1585
Lorcaserinh	159	6.7	1	190	6.0	1	29	7.9	1	16
SB242084f	851	6.8	–	45	7.0	–	7.0	9	–	158

^aKi: binding affinity.

^bpEC50, potency: negative logarithm of the EC50 (half-maximal effective concentration).

^cEfficacy relative to response to a supramaximal 5-HT concentration.

^d(McLean et al., 2006).

^e(Pehek et al., 2006).

^f(Bromidge et al., 1997).

^g(Siuciak et al., 2007).

^h(Thomsen et al., 2008).

ⁱModified from (Higgins et al., 2013a).