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Activity vs logD of active 4(5)-nitroimidazoles. Compounds were classified as active against G. lamblia and E. histolytica with EC50 < 50 μM and were considered active against T. vaginalis with EC50 < 20 μM. All 4(5)-nitroimidazoles were classified as active against C. difficile (MIC ≤ 16 μg/mL). Metronidazole (black symbols) is shown for comparison.
