Scheme 1.
Synthesis of 1-methyl-5-nitroimidazoles 8a-k. i) KMnO4, acetone, −5 °C → rt, 85%; ii) oxalyl chloride, cat. DMF, DCM, 0 °C → rt; iii) amine, TEA, DCM, 0 °C → rt, 19–58%.
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