Risk of developing ESRD or death in 5 years stratified by year of diagnosis, shown as Kaplan-Meier curve (1A) and multivariable Cox proportional hazards curve (1B). Patients diagnosed in earlier time periods have poorer ESRD-free survival. Multivariable analysis adjusted for age, race, ANCA type, site, baseline serum creatinine, duration of cyclophosphamide use, and occurrence of relapse. Time period 1985–1989 combined with time period 1990–1994 due to missing cyclophosphamide data in the 1985–1989 group.