Table 1.
AKI (n=12) | No AKI (n=137) | p-value | |
---|---|---|---|
Continuous variables Mean (SD) | |||
Age (yrs) | 8.7 (5.3) | 9.8 (4.8) | 0.5 |
Baseline Hb (g/dL) | 8.8 (0.9) | 8.9 (1.6) | 0.96 |
Admission Hb (g/dL) | 6.4 (2.0) | 7.5 (1.7) | 0.03 |
Drop in Hb (g/dL) | 2.7(1.9) | 1.4 (1.4) | 0.003 |
Admission WBC ×109/L | 33.1 (16.2) | 19.8 (9.7) | <0.0001 |
Admission Platelet count ×109/L | 297 (145) | 332(184) | 0.5 |
Nominal Variables | |||
Phenotype | AKI pts | No AKI pts | |
Severe SCD (SS, SB0 thalassemia, SD) (n=127) | 10 (8%) | 117 (92%) | 0.8 |
Mild SCD (n=22) | 2 (9%) | 20 (91%) | |
Disease Modifying Therapy | |||
No therapy (n=95) | 10 (11%) | 85 (89%) | 0.3 |
Hydroxyurea (n=50) | 2 (4%) | 48 (96%) | |
Transfusions (n=4) | 0 (0%) | 4 (100%) |
ACS=acute chest syndrome, AKI=acute kidney injury, SCD=sickle cell disease