Table 3.
Up- or down-regulated genes in day 5 (n = 5) and 7 (n = 3) after TNBS treatment over ethanol (n = 3)
| Day 5
|
Day 7
|
||
|---|---|---|---|
| Gene | Folds | Gene | Folds |
| IL1B | 36.65* | CD1D | 14.28* |
| LBP | 29.33 | LBP | 6.86 |
| IL8 | 23.64* | FAS | 6.47 |
| IL1A | 18.37* | IL6 | 6.31* |
| IL6 | 11.94* | IL8 | 4.97 |
| RAG1 | 10.28 | Cox2 | 3.52 |
| CD1D | 8.40* | IRAK1 | 3.43 |
| ITGB2 | 5.88* | NOD2 | 2.69 |
| CCL3 | 4.90* | NOD1 | 2.56 |
| IL1R1 | 4.45* | CRP | 2.25 |
| CCR6 | 4.43 | IL1B | 2.10 |
| IFNa1 | 4.25 | ITGB2 | 1.94 |
| Cox2 | 3.57 | STAT3 | 1.85 |
| FAS | 3.36 | NFkB2 | 1.79 |
| CD4 | 3.33 | CD209 | 1.71 |
| TLR4 | 2.87* | RAG1 | 1.64 |
| MBL2 | 2.82 | TICAM2 | 1.56 |
| CD1A | 2.61 | ITGAM | 1.55 |
| CCR4 | 2.47 | CD40 | 1.53 |
| ITGAM | 2.33 | MAPK1 | 1.53 |
| CCL2 | 2.19 | C-JUN | 1.52 |
| CD40 | 2.16 | LDHA | 1.43 |
| IL13 | 2.16 | FoxP3 | 1.42 |
| CCR8 | 2.02 | TYK2 | 1.41 |
| NOD1 | 1.96 | GAPDH | 1.33 |
| CD28 | 1.93 | MBL2 | 1.27 |
| NOD2 | 1.92 | CCL2 | 1.24 |
| TICAM2 | 1.91 | CD1A | 1.23 |
| CD40L | 1.85 | MIF | 1.22 |
| IL4 | 1.79 | ACTA2 | 1.22 |
| CCR5 | 1.74 | MAPK3 | 1.21 |
| IL2 | 1.74 | STAT6 | 1.12 |
| CRP | 1.72 | CCR8 | 1.10 |
| MPO | 1.66 | MAPK8 | 1.08 |
| FoxP3 | 1.60 | CCL3 | 1.08 |
| STAT3 | 1.54 | TLR4 | 1.08 |
| LDHA | 1.53 | IL1R1 | 1.07 |
| FasL | 1.51 | CCR5 | 1.06 |
| ACTA2 | 1.50 | IL13 | 1.06 |
| TNF | 1.50 | MAPK14 | −1.01 |
| RORC | 1.47 | IkBa | −1.01 |
| IkBa | 1.44 | IL4 | −1.01 |
| IL15 | 1.44 | IL23a | −1.01 |
| TYK2 | 1.43 | MPO | −1.04 |
| Myd88 | 1.40 | IFNa1 | −1.04 |
| IRAK1 | 1.37 | CCR6 | −1.06 |
| NFkB2 | 1.34 | CD4 | −1.08 |
| CD14 | 1.32 | IL1A | −1.15 |
| CXCR3 | 1.30 | CD40L | −1.17 |
| IL17A | 1.29 | CCR4 | −1.18 |
| MAPK1 | 1.25 | Myd88 | −1.21 |
| NLRP3 | 1.24 | TRAF6 | −1.24 |
| C-JUN | 1.17 | GATA3 | −1.24 |
| IL23a | 1.17 | MEFV | −1.27 |
| GATA3 | 1.17 | STAT1 | −1.28 |
| MIF | 1.13 | CD14 | −1.30 |
| STAT6 | 1.12 | CD28 | −1.31 |
| MEFV | 1.07 | IL2 | −1.32 |
| TLR2 | 1.07 | TNF | −1.32 |
| ACTB | 1.04 | NLRP3 | −1.35 |
| MAPK3 | 1.01 | NONO | −1.44 |
| IFIH1 | −1.02 | LYZ | −1.53 |
| IRF1 | −1.03 | ACTB | −1.53 |
| CD209 | −1.06 | TLR6 | −1.61 |
| DDX58 | −1.08 | IFNG | −1.62 |
| STAT4 | −1.15 | DDX58 | −1.65 |
| STAT1 | −1.15 | CD80 | −1.67 |
| TRAF6 | −1.20 | IFIH1 | −1.73 |
| LYZ | −1.21 | IL17A | −1.78 |
| MAPK8 | −1.21 | IL15 | −1.78 |
| GAPDH | −1.23 | TLR2 | −1.80 |
| MAPK14 | −1.24 | RORC | −2.02 |
| TLR6 | −1.35 | IRF1 | −2.04 |
| IL10 | −1.37 | MX1 | −2.04 |
| IFNG | −1.41 | IL5 | −2.09 |
| TLR1 | −1.41 | CXCR3 | −2.44 |
| NONO | −1.47 | IL10 | −2.50 |
| CD80 | −1.60 | LY96 | −2.75 |
| LY96 | −1.68 | STAT4 | −2.76 |
| IRF6 | −1.70 | TLR1 | −2.85 |
| CD86 | −1.85* | FasL | −2.92 |
| IL5 | −1.86 | JAK2 | −2.99 |
| Caspase-1 | −1.93 | C3 | −2.99* |
| TLR3 | −2.00 | TLR3 | −3.17 |
| JAK2 | −2.19 | CXCR4 | −3.31* |
| C3 | −2.27* | CD86 | −3.78* |
| MX1 | −2.69 | IL18 | −4.92* |
| CXCR4 | −2.98* | Caspase-1 | −6.01 |
| IL18 | −3.36* | IRF6 | −20.97 |
Bold values indicate >3-fold changes
*
p < 0.05 indicates a statistically significant change by the Student’s t test compared to the ethanol group