FIG. 7.

MRI and DOT images of the left breast of a 79-year-old post-menopausal Caucasian female with breast cancer, viewed as lateral to medial sagittal slices from the upper left. (a) Subtraction images from a DCE-MRI (Gadolinium). Tumor biopsy confirmed as invasive mammary carcinoma (ductal and lobular features) with intermediate grade nuclei. (b) 3D multispectral frequency-domain DOT reconstruction of the HbO₂ and Hb concentrations (μM) as well as the ${\mu }_s^{\prime }$ at 785 nm. The approximate tumor location in the MRI, as well as the corresponding area in each DOT image, is indicated by a dashed circle of 30 mm in diameter. Note, MRI and DOT breast compressions are similar but are not identical. Interesting features are apparent in the images with high HbO₂, Hb, and scattering near the tumor region (identified with biopsy clip in the MRI).