Figure 1.

Transcriptional Initiation at Th1 and Th2 Genes in Both Lineages

(A) Average number of ChIP-seq reads for RNA pol II (reads/million) across Th1 genes (left) and Th2 genes (right) in unstimulated (US) or restimulated (RS) human Th1 and Th2 cells.

(B) Log2 ratio of RNA pol II across Th1 genes (left) and Th2 genes (right) between RS Th1 and Th2 cells. The difference in RNA pol II levels increases across the genes.

(C) As in (A), except for H3K3me3 in Th1 and Th2 cells polarized for an extended period of time.

(D) As in (A), except for H3K4me3 in CCR5+ Th1 memory cells.

(E) ChIP-seq binding profiles for RNA pol II and H3K4me3 at example Th1 genes and Th2 genes in in vitro polarized Th1 and Th2 cells and in CCR5+ Th1 memory cells.

See also Figure S1.