Table 1.

Examples of the variation of the transition probabilities at the sequence identity of 80 % between Markovian (P) and non-Markovian ($\tilde{P}$) dynamics

Initial state	Final state	P(t)	$\tilde{P}\left(\tilde{t}\right)$	$P\left(t\right)/\tilde{P}\left(\tilde{t}\right)$
ATC	TGG	5.21·10−8	8.23·10−6	0.006
TTC	ATG	3.39·10−5	3.09·10−4	0.110
GTC	GTT	0.1507	0.0951	1.58
Ile	Val	0.104	0.076	1.4
Arg	Lys	0.064	0.049	1.3
Gly	Ile	0.0006	0.0022	0.3

The first three rows involve substitutions in the framework of codons, while the last three are in the framework of amino acids