Table 2.
Adverse events during the treatment period (n = 33)
| Grade | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | All, % | 3/4, % | |
| Adverse events during induction chemotherapy | ||||||
| Hematologic | ||||||
| Leukopenia | 5 | 15 | 11 | 2 | 100 | 39 |
| Neutropenia | 0 | 9 | 12 | 12 | 100 | 72 |
| Anemia | 22 | 11 | 0 | 0 | 100 | 0 |
| Thrombocytopenia | 22 | 11 | 0 | 0 | 100 | 0 |
| Non-hematologic | ||||||
| Creatinine increased | 7 | 0 | 0 | 0 | 21 | 0 |
| Elevation of AST | 14 | 0 | 0 | 0 | 42 | 0 |
| Elevation of ALT | 10 | 9 | 1 | 0 | 30 | 3 |
| Febrile neutropenia | – | – | 1 | 1 | 6 | 6 |
| Hyperbilirubinemia | 3 | 1 | 0 | 0 | 12 | 0 |
| Hyponatremia (≥G3) | – | – | 1 | 1 | 6 | 6 |
| Alopecia | 14 | 6 | 0 | 0 | 60 | 0 |
| Anorexia | 10 | 13 | 6 | 0 | 87 | 18 |
| Constipation | 8 | 6 | 0 | 0 | 42 | 0 |
| Diarrhea | 9 | 3 | 0 | 0 | 38 | 0 |
| Dysphagia | 7 | 6 | 4 | 0 | 51 | 12 |
| Edema | 2 | 0 | 1 | 0 | 9 | 3 |
| Fever | 2 | 0 | 1 | 0 | 9 | 3 |
| Fistula GI-esophagus | 0 | 0 | 1 | 0 | 3 | 3 |
| Infection with normal ANC | 0 | 0 | 1 | 1 | 6 | 6 |
| Nausea | 13 | 7 | 3 | 0 | 69 | 9 |
| Rash | 3 | 0 | 0 | 0 | 9 | 0 |
| Stomatitis | 11 | 6 | 1 | 0 | 54 | 3 |
| Vomiting | 3 | 2 | 0 | 0 | 15 | 0 |
| Adverse events during chemoradiation | ||||||
| Hematologic | ||||||
| Leukopenia | 5 | 15 | 8 | 0 | 85 | 24 |
| Neutropenia | 11 | 10 | 6 | 0 | 82 | 18 |
| Anemia | 6 | 22 | 1 | 0 | 88 | 3 |
| Thrombocytopenia | 9 | 2 | 0 | 0 | 33 | 0 |
| Non-hematologic | ||||||
| Creatinine increased | 8 | 1 | 0 | 0 | 27 | 0 |
| Elevation of AST | 5 | 0 | 0 | 0 | 15 | 0 |
| Elevation of ALT | 0 | 7 | 0 | 0 | 21 | 0 |
| Febrile neutropenia | – | – | 1 | 0 | 3 | 3 |
| Alopecia | 14 | 8 | 0 | 0 | 67 | 0 |
| Anorexia | 12 | 6 | 4 | 0 | 67 | 12 |
| Constipation | 9 | 0 | 0 | 0 | 27 | 0 |
| Diarrhea | 4 | 0 | 0 | 0 | 12 | 0 |
| Dysphagia | 8 | 8 | 5 | 0 | 64 | 15 |
| Edema | 1 | 1 | 0 | 0 | 6 | 0 |
| Esophagitis (≥G3) | – | – | 4 | 0 | – | 12 |
| Fever | 2 | 0 | 0 | 0 | 6 | 0 |
| Fistula GI-esophagus | 0 | 0 | 1 | 0 | 3 | 3 |
| Infection with normal ANC | 1 | 0 | 1 | 0 | 6 | 3 |
| Nausea | 12 | 3 | 3 | 0 | 55 | 9 |
| Neuropathy sensory | 2 | 0 | 0 | 0 | 6 | 0 |
| Stomatitis | 4 | 0 | 0 | 0 | 12 | 0 |
| Vomiting | 3 | 1 | 0 | 0 | 12 | 0 |