Skip to main content
. Author manuscript; available in PMC: 2016 Jun 26.
Published in final edited form as: Annu Rev Virol. 2015 Jul 2;2(1):311–333. doi: 10.1146/annurev-virology-100114-054839

Figure 3.

Figure 3

Herpesvirus infection alters the global translational landscape of an infected cell. During herpes simplex virus 1 (HSV-1) and Kaposi’s sarcoma–associated herpesvirus (KSHV) infection the pool of mRNAs available for translation is significantly reduced due to mRNA degradation by the viral endonucleases vhs and SOX, respectively. In addition, vhs has the ability to stimulate translation of select mRNAs, such as those containing internal ribosome entry site (IRES) elements, in a manner independent of its mRNA degradation function. During human cytomegalovirus (HCMV) infection, translation is broadly impacted through increased abundance of multiple translation factors. This leads to both large-scale enhancement and repression of mRNAs associated with polysomes.