Table 1.
Disease | Transporter/channel function | Augmented chemokines/cytokines | |
---|---|---|---|
Airway system | CF | CFTR ↓ | CXCL8, CXCL1, CXCL2, CCL3, CCL18, IL-1β, IL-6, IL-33, TNFα, GM-CSF, G-CSF, HMGB1 |
COPD | CFTR ↓ | CXCL8, CXCL1, CCL2, CCL8, CCL18, IL-6 | |
Asthma | CFTR∗
SLC26A4 ↑ TMEM16A ↑ SLC26A9 ↓ |
CXCL8, IL-1β, IL-6, IL-13, TGF-β1, GM-CSF | |
| |||
Gastrointestinal system | Pancreatitis | CFTR∗
CFTR ↓ SLC26A3/A6 ↓ |
CXCL8, IL-1, IL-6, TNF-α |
Cholestatic liver diseases | CFTR∗
CFTR ↓ AE2 ↓ |
CXCL8, CXCL1, CXCL5, CXCL6, CXCL10, CCL2, CCL3, CCL4, CCL5, |
CFTR∗: carriers of CFTR mutations have an increased risk to develop disease.