Table 1.
Patient Characteristics
| Alcohol Dependent (n = 521) | Controls (n = 288) | Test for Group Differences | |
|---|---|---|---|
| Demographics
| |||
| Age | 42.1 (9.9) | 31.3 (10.9) | t = 13.9, p < 0.0001 |
| Female | 159 (30.5%) | 111 (38.5%) | χ2 = 5.4, p = 0.02 |
| Caucasian1 | 308 (59.1%) | 186 (64.6%) | χ2 = 59.9, p = 0.007 |
| Body Mass Index | 26.6 (5.5) | 25.9 (4.9) | t = 2.03, p = 0.04 |
|
| |||
| Genotype
| |||
| rs22355442 | AA: 110 (21.2%) | AA: 60 (20.8%) | χ2 = 0.2, p = 0.92 |
| AC: 244 (46.9%) | AC: 132 (45.8%) | ||
| CC: 166 (31.9%) | CC: 96 (33.3%) | ||
| rs225015 | AA: 181 (34.7%) | AA: 104 (36.1%) | χ2 = 0.4, p = 0.84 |
| AG: 245 (47.0%) | AG: 136 (47.2%) | ||
| GG: 95 (18.2%) | GG: 48 (16.7%) | ||
| rs128853003 | AA/AG: 219 (42.4%) | AA/AG: 138 (47.9%) | χ2 = 2.3, p = 0.13 |
| GG: 298 (57.6%) | GG: 150 (52.1%) | ||
|
| |||
| Alcohol Use (90 days)
| |||
| Total Drinks | 1062.4 (721.0) | 158.5 (180.1) | t = 26.6, p < 0.0001 |
| Number of Drinking Days | 70.9 (22.0) | 36.1 (24.7) | t = 17.7, p < 0.0001 |
| Number of Non-Drinking Days | 18.8 (21.9) | 53.5 (24.8) | t = −17.6, p < 0.0001 |
| Average Drinks/day | 14.5 (8.0) | 3.7 (2.5) | t = 27.6, p < 0.0001 |
| Heavy Drinking Days | 65.6 (25.6) | 14.5 (20.3) | t = 28.3, p < 0.0001 |
| Number of Days Abstinent before TSH level | 2.4 (3.7) | 4.1 (7.0) | T = −3.27, p = 0.001 |
|
| |||
| Major Depression
| |||
| Current Diagnosis | 57 (10.9%) | 3 (1.1%) | χ2 = 25.5, p < 0.0001 |
1
A majority of the remaining subjects were Black/African American.
2
Missing genotype data for 1 subject
3
Missing genotype data for 4 subjects. AG and AA subjects were combined due to the small number of AA homozygotes