. Author manuscript; available in PMC: 2016 Sep 1.

Published in final edited form as: Alcohol Clin Exp Res. 2015 Jul 24;39(9):1665–1670. doi: 10.1111/acer.12814

Table 2.

Genotype differences in patient characteristics

		Full Sample (N = 809)				Alcohol Dependent Patients (N = 521)

SNP	Variable
rs2235544		AA	AC	CC		AA	AC	CC

	Age	37.7	37.7	39.3	F = 1.74	41.8	41.6	43.0	F = 1.03
		(11.6)	(11.5)	(11.3)	p = 0.18	(10.0)	(10.0)	(9.7)	p = 0.36
	Female	62	113	95	χ² = 3.6	38	66	55	χ² = 2.8
		(36.5%)	(30.1%)	(36.3%)	p = 0.17	(34.6%)	(27.1%)	(33.1%)	p = 0.25
	Caucasian¹	126	250	118	χ² = 94.5	84	157	67	χ² = 61.1
		(74.12%)	(66.5%)	(45.0%)	p < 0.0001	(76.4%)	(64.3%)	(40.4%)	p < 0.0001
	Body Mass Index	26.0	26.3	26.6	F = 0.58	26.9	26.7	26.3	F = 0.33
		(4.9)	(5.7)	(4.8)	p = 0.56	(5.2)	(6.0)	(4.7)	p = 0.72
rs225014		AA	AG	GG		AA	AG	GG

	Age	38.5	38.3	37.7	F = 0.23	42.6	41.9	41.4	F = 0.56
		(11.9)	(11.4)	(10.8)	p = 0.80	(10.4)	(9.7)	(9.5)	p = 0.57
	Female	90	132	48	χ² = 0.7	58	76	25	χ² = 1.0
		(31.6%)	(34.7%)	(33.6%)	p = 0.71	(32.0%)	(31.0%)	(26.3%)	p = 0.60
	Caucasian¹	197	225	72	χ² = 15.4	122	138	48	χ² = 9.4
		(69.1%)	(59.1%)	(50.4%)	p = 0.004	(67.4%)	(56.3%)	(50.5%)	p = 0.05
	Body Mass Index	26.4	26.3	26.5	F = 0.07	26.6	26.8	26.5	F = 0.11
		(4.8)	(6.7)	(4.9)	p = 0.93	(4.7)	(6.2)	(4.8)	p = 0.89
rs12885300		AA/AG		GG		AA/AG		GG

	Age	37.8		38.6	F = 1.01	41.9		42.3	F = 0.19
		(11.8)		(11.2)	p = 0.32	(10.3)		(9.6)	p = 0.66
	Female	126		144	χ² = 0.9	75		84	χ² = 2.18
		(46.7%)		(53.3%)	p = 0.35	(34.3%)		(28.2%)	p = 0.14
	Caucasian¹	278		213	χ² = 92.4	168		137	χ² = 59.6
		(77.9%)		(47.6%)	p < 0.0001	(76.7%)		(46.0%)	p < 0.0001
	Body Mass Index	26.2		26.5	F = 0.49	26.5		36.7	F = 0.06
		(5.7)		(4.9)	p = 0.48	(6.0)		(5.0)	p = 0.80

A majority of the remaining subjects were Black/African American