Table 4.

Longitudinal cluster by treatment interaction effects on longitudinal change in metabolic biomarkers and cognitive composite scores

	HEALTHY METABOLIC: HT vs. Placebo		HIGH BP: HT vs. Placebo		POOR METABOLIC: HT vs. Placebo		B. Cluster- Treatment Interaction p- value
	A. Pairwise Comparisons
	HT Effect (SEM)	p-value	HT Effect (SEM)	p-value	HT Effect (SEM)	p-value	B. Cluster- Treatment Interaction p- value
*Metabolic Biomarkers*
Glucose (mg/dL)	−0.126 (0.36)	0.73	−0.239 (0.38)	0.53	0.280 (0.53)	0.60	0.73
HOMA Score	−0.010 (0.01)	0.47	−0.037 (0.02)	0.017	−0.021 (0.02)	0.32	0.46
Ketones (mM)	0.016 (0.01)	0.21	−0.022 (0.01)	0.10	−0.010 (0.02)	0.58	0.11
HDL Cholesterol (mg/dL)	0.275 (0.35)	0.43	0.270 (0.37)	0.46	1.098 (0.51)	0.031	0.35
LDL Cholesterol (mg/dL)	−0.733 (0.96)	0.44	−2.962 (1.01)	0.004	−1.311 (1.40)	0.35	0.26
Triglycerides (mg/dL)	0.024 (0.01)	0.019	0.005 (0.01)	0.65	0.003 (0.01)	0.84	0.33
HbA1c (%)	−0.010 (0.01)	0.35	−0.013 (0.01)	0.26	−0.031 (0.02)	0.049	0.53
Systolic Blood Pressure (mmHg)	−0.460 (0.41)	0.26	−0.035 (0.43)	0.94	−0.178 (0.60)	0.77	0.77
Diastolic Blood Pressure (mmHg)	−0.076 (0.28)	0.78	−0.265 (0.29)	0.36	0.023 (0.40)	0.95	0.82

*Cognitive Performance*
Global Cognition	−0.028 (0.05)	0.48	0.015 (0.04)	0.71	−0.046 (0.06)	0.42	0.63
Verbal Memory	−0.053 (0.04)	0.16	−0.056 (0.04)	0.16	−0.065 (0.06)	0.24	0.98
Executive Functions	0.001 (0.03)	0.96	−0.0008 (0.02)	0.97	0.012 (0.03)	0.73	0.95

A. Pairwise comparisons of the magnitude of longitudinal change between women randomized to HT and those randomized to placebo within each metabolic phenotype. Data are presented as estimate (SEM). B. Cluster by treatment interaction effect on the longitudinal trajectory of the nine metabolic biomarkers and three cognitive composite scores.