Table 6.
Study end metabolic and cognitive values in women randomized to HT
| Pairwise Comparisons | |||||
|---|---|---|---|---|---|
| HEALTHY METABOLIC |
HIGH BLOOD PRESSURE |
HEALTHY METABOLIC |
Main Effect of Cluster at Study End |
||
| A. Metabolic Biomarkers | |||||
| Glucose (mg/dL) | 81.42 (0.98) | 80.07 (1.05) | 93.66 (1.50) ab | <0.0001 | |
| HOMA Score | −0.12 (0.05) | 0.01 (0.06) | 0.75 (0.08) ab | <0.0001 | |
| Ketones (mM) | −2.35 (0.04) | −2.43 (0.04) | −2.46 (0.06) | 0.24 | |
| HDL Cholesterol (mg/dL) | 79.28 (1.86) | 74.19 (1.99) | 55.99 (2.82) ab | <0.0001 | |
| LDL Cholesterol (mg/dL) | 112.91 (3.37) | 120.38 (3.61) | 115.24 (5.13) | 0.31 | |
| Triglycerides (mg/dL) | 4.46 (0.04) | 4.54 (0.05) | 4.89 (0.07) ab | <0.0001 | |
| HbA1c (%) | 5.67 (0.03) | 5.65 (0.04) | 5.95 (0.05) ab | <0.0001 | |
| Systolic Blood Pressure (mmHg) | 108.23 (1.31) | 117.19(1.40) a | 116.87 (1.98) a | <0.0001 | |
| Diastolic Blood Pressure (mmHg) | 69.47 (0.80) | 73.46 (0.86) a | 74.30 (1.22) a | 0.0004 | |
| B. Cognitive Performance | |||||
| Global Cognition | 0.89 (0.18) | 0.87 (0.19) | 0.52 (0.27) | 0.50 | |
| Verbal Memory | 0.84 (0.15) | 0.47 (0.16) | 0.34 (0.22) | 0.10 | |
| Executive Functions | 0.23 (0.13) | 0.32 (0.14) | 0.07 (0.19) | 0.59 | |
A. Average (SEM) value at study end for each metabolic biomarker within each phenotype. HOMA, ketones, and triglycerides are expressed as log values due to a skewed distribution of values within the population. B. Average (SEM) value at study end for each cognitive composite score within each phenotype.
Significant longitudinal change from baseline (p < 0.05).
Longitudinal change is significantly different from the Healthy phenotype (p < 0.05).
Longitudinal change is significantly different from the High BP phenotype (p < 0.05). ANCOVA was used to test for overall cross-sectional differences among metabolic clusters on each biomarker and cognitive composite score. The Tukey-Kramer method was used to adjust for multiple comparisons.