Table 7.

Study end cluster by treatment interaction effects on metabolic biomarkers and cognitive composite scores

		A. Pairwise Comparisons
		HEALTHY METABOLIC: HT vs. Placebo		HIGH BP: HT vs. Placebo		POOR METABOLIC: HT vs. Placebo		B. Cluster- Treatment Interaction p-value
		HT Effect (SEM)	p-value	HT Effect (SEM)	p-value	HT Effect (SEM)	p-value
Metabolic Biomarkers
Glucose (mg/dL)		0.034 (−4.11, 4.17)	1.00	−1.419 (−5.86, 3.02)	0.94	2.148 (−4.07, 8.36)	0.92	0.41
HOMA Score		−0.082 (−0.31, 0.14)	0.90	−0.196 (−0.44, 0.05)	0.20	−0.042 (−0.38, 0.30)	1.00	0.49
Ketones (mM)		0.016 (−0.14, 0.18)	1.00	−0.020 (−0.19, 0.15)	1.00	−0.078 (−0.32, 0.16)	0.94	0.65
HDL Cholesterol (mg/dL)		−0.707 (−8.57, 7.15)	1.00	5.157 (−3.28, 13.59)	0.50	−0.469 (−12.27, 11.33)	1.00	0.30
LDL Cholesterol (mg/dL)		−6.59 (−20.64, 7.45)	0.76	−2.44 (−17.52,12.63)	1.00	−6.092 (−27.19, 15.00)	0.96	0.83
Triglycerides (mg/dL)		0.044 (−0.13, 0.22)	0.98	0.010 (−0.17, 0.19)	1.00	0.058 (−0.20, 0.31)	0.99	0.89
HbA1c (%)		−0.105 (−0.27, 0.06)	0.44	0.015 (−0.16, 0.19)	1.00	−0.172 (−0.42, 0.07)	0.34	0.16
Systolic Blood Pressure (mmHg)		0.174 (−5.05, 5.40)	1.00	−0.101 (−5.71, 5.51)	1.00	−1.222 (−9.07, 6.63)	1.00	0.91
Diastolic Blood Pressure (mmHg)		0.126 (−3.09, 3.34)	1.00	−1.907 (−5.36, 1.54)	0.61	0.565 (−4.26, 5.39)	1.00	0.36
Cognitive Performance
Global Cognition		0.022 (−0.71, 0.76)	1.00	0.263 (−0.53, 1.05)	0.93	−0.214 (−1.33, 0.90)	0.99	0.59
Verbal Memory		0.222 (−0.35, 0.79)	0.87	−0.168 (−0.78, 0.44)	0.97	−0.106 (−0.97, 0.75)	1.00	0.37
Executive Functions		−0.057 (−0.59, 0.48)	1.00	0.340 (−0.23, 0.91)	0.53	0.052 (−0.76, 0.86)	1.00	0.34

A. Pairwise comparisons of values at study end between women randomized to HT and those randomized to placebo within each metabolic phenotype. Data are presented as estimate (95% confidence interval). B. Cluster by treatment interaction effect on the study end values of the nine metabolic biomarkers and three cognitive composite scores.