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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Biomaterials. 2016 Jun 2;101:189–198. doi: 10.1016/j.biomaterials.2016.05.050

Figure 8.

Figure 8

a) Addition of increasing concentrations of 13k-4 to B cells incubated with 450k-40 glycopolymer (8.4 μM Tn concentration) suppressed the generation of Tn specific ASCs; b) Addition of 13k-4 to B cells incubated with wheat germ agglutinin (1 μg/mL) did not have any significant effects on wheat germ agglutinin specific ASCs. c) Co-administration of 450k-40 (Tn 4 μg) and 13k-4 (Tn 1 μg) to mice significantly reduced IgM titers compared to mice receiving 450k-40 (Tn 4 μg) only. Blood was collected on day 4 and day 8 following immunization. Statistical analysis was performed using Student’s t test (** p < 0.01). These results suggest 13k-4 glycopolymer selectively induced non-responsiveness of Tn specific ASCs.