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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Methods. 2016 Mar 10;103:167–174. doi: 10.1016/j.ymeth.2016.03.003

Fig. 1.

Fig. 1

Predicted tertiary structure of PSMA RNA aptamer A9g. The predicted tertiary structure (3D) of A9g was obtained as described in Rockey et al. (2011). The constructed PDB files were then processed using the Swiss PDBViewer to generate the 3D structure. This aptamer is chemically modified with 2′ fluoro chemistry for clinical applications. A9g is a non-competitive inhibitor of PSMA enzymatic activity. It inhibits PSMA-mediated migration and invasion of prostate cancer cells in culture and dissemination in a mouse model of metastatic bone disease.