Table 3.
Adjusted Hazard Ratios of incident events Note: HRs are per unit decrease in z score, representing a standard deviation decrease in the marker.
| Age-sex-race Adjusted | Multivariable adjusted§ | Multivariable§+mGFR§§ | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p vs. eGFRcr** |
HR (95% CI) | p vs. eGFRcr** |
HR (95% CI) | p vs. eGFRcr** |
|
| ESRD (755 events/3613 participants) | ||||||
| mGFR, n=1324 | 4.67 (3.86, 5.64)* | 0.1 | 3.51 (2.85, 4.31)* | 0.3 | - | - |
| eGFRcr | 4.03 (3.63, 4.48)* | - | 3.18 (2.84, 3.55)* | - | 2.55 (1.96, 3.32)* | - |
| 1/BTP | 8.55 (7.28, 10.04)* | <0.001 | 4.59 (3.86, 5.45)* | <0.001 | 2.84 (1.92, 4.18)* | 0.6 |
| 1/B2M | 4.81 (4.29, 5.41)* | <0.001 | 3.56 (3.13, 4.04)* | 0.01 | 2.52 (1.89, 3.36)* | 0.9 |
| Combination | 5.52 (4.90, 6.22)* | <0.001 | 4.10 (3.61, 4.66)* | <0.001 | 4.80 (3.31, 6.94)* | <0.001 |
| All-Cause Mortality (653 events/3613 participants) | ||||||
| mGFR, n=1324 | 1.90 (1.54, 2.35)* | 0.1 | 1.36 (1.08, 1.71)^ | 0.7 | - | - |
| eGFRcr | 1.59 (1.44, 1.74)* | - | 1.30 (1.18, 1.44)* | - | 0.73 (0.55, 0.97)^ | - |
| 1/BTP | 1.96 (1.75, 2.20)* | <0.001 | 1.52 (1.34, 1.74)* | 0.02 | 1.13 (0.84, 1.53) | 0.03 |
| 1/B2M | 2.32 (2.09, 2.58)* | <0.001 | 1.93 (1.71, 2.18)* | <0.001 | 1.59 (1.13, 2.25)^ | <0.001 |
| Combination | 2.46 (2.21, 2.74)* | <0.001 | 2.03 (1.80, 2.29)* | <0.001 | 1.77 (1.31, 2.38)* | <0.001 |
| Cardiovascular Events (292 events/2405 participants free of CVD at baseline) | ||||||
| mGFR, n=978 | 1.58 (1.26, 1.98)* | 0.4 | 1.10 (0.86, 1.42) | 0.8 | - | - |
| eGFRcr | 1.46 (1.28, 1.66)* | - | 1.07 (0.93, 1.23) | - | 0.86 (0.62, 1.20) | - |
| 1/BTP | 1.87 (1.58, 2.20)* | <0.001 | 1.16 (0.98, 1.39) | 0.2 | 1.03 (0.73, 1.46) | 0.4 |
| 1/B2M | 2.05 (1.78, 2.37)* | <0.001 | 1.45 (1.22, 1.72)* | <0.001 | 1.69 (1.14, 2.51)^ | 0.002 |
| Combination | 2.16 (1.86, 2.50)* | <0.001 | 1.64 (1.38, 1.96)* | <0.001 | 1.75 (1.28, 2.41)* | 0.01 |
CI, confidence interval; HR, hazard ratio; mGFR, measured glomerular filtration rate; eGFRcr, creatinine-based estimated glomerular filtration rate; BTP, β-trace protein; B2M, β2-microglobulin
p<0.05,
p<0.001 for 1-unit decline in z score in Cox proportional hazards regression models.
Multivariable model adjusted for age, sex, race, diabetes, hypertension, prevalent cardiovascular disease, smoking status, high density lipoprotein cholesterol, natural log-transformed C-reactive protein, natural log transformed urinary albumin-creatinine ratio.
Comparison to eGFRcr performed in seemingly unrelated regression models with same adjustment variables as appropriate for column.
HRs from multivariable model additionally adjusted for mGFR and performed in the subset of participants with mGFR.