Table 4.

C statistics, Likelihood Ratio Test P-Values, and the 2.5-Year RIDI and Continuous NRI for Multivariable Models with eGFRcr and with the 4-marker Composite Score

Outcome	C statistic With eGFR	C statistic With 4-marker Composite	Difference in C- statistic (95% CI)	Likelihood Ratio Test P-Value	RIDI (95% CI)	Continuous NRI (95% CI)
ESRD	0.888	0.895	0.007 (0.004–0.010)	<0.001	0.026 (0.006–0.047)	0.252 (0.130–0.374)
All-cause Mortality	0.744	0.770	0.026 (0.017–0.036)	<0.001	0.233 (0.162–0.304)	0.446 (0.304–0.588)
Cardiovascular Events	0.765	0.780	0.015 (0.004–0.025)	<0.001	0.185 (0.094–0.276)	0.392 (0.216–0.567)

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; HR, hazard ratio; RIDI, relative integrated discrimination improvement; mGFR, measured glomerular filtration rate; NRI, net reclassification improvement.

Note: Multivariable models adjusted for age, sex, race/ethnicity, diabetes, hypertension, prevalent cardiovascular disease, smoking status, high density lipoprotein cholesterol, natural log-transformed C-reactive protein, natural log transformed urinary albumin-creatinine ratio