Table. Comparison of the JTF and EAACI urticaria guidelines step treatment.

	Step 1	Step 2	Step 3	Step 4	Oral steroids OK?
JTF	Antihistamine monotherapy	One or more:  1) Dose escalation of 2nd generation antihistamine  2) Add another 2nd generation antihistamine  3) Add H2 antagonist  4) Add leukotriene receptor antagonist  5) Add 1st generation antihistamine at bedtime	Dose advancement of potent antihistamine as tolerated	Add an alternative agent:  1) Omalizumab or cyclosporine  2) Other anti-inflammatory agents, immunosuppressants or biologics	Yes, short term (1-3 weeks)
EAACI	Modern 2nd generation antihistamine	Increase dosage up to fourfold of modern 2nd generation antihistamine	Add: Omalizumab or Cyclosporine A or Montelukast	N/A	Yes, short term (10 days)