Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Attenuation of glucose-stimulated somatostatin secretion by ghrelin depends on local feedback mediated by Sst and Sst3r. Ghrelin significantly attenuates glucose-stimulated insulin secretion from wild type mouse islets in vitro. Co-stimulation with an Sstr3 antagonist fully prevents the insulinostatic actions of ghrelin. All peptides were applied at 100 nM final concentration. Values represent the mean ± SEM for 4 wells per group. *P < 0.05; **P < 0.01; ***P < 0.001.
