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. 2016 Apr 22;5(7):527–537. doi: 10.1016/j.molmet.2016.04.004

Figure 2.

Figure 2

G0S2 inhibits ATGL activity in mouse and human skeletal muscle. (A) Representative blots of G0S2 and CGI-58 protein content in mouse extensor digitorum longus (EDL), gastrocnemius (Gast), and soleus skeletal muscles. Triacylglycerol hydrolase activity (TAGH) was measured in absence (control) or presence of recombinant human G0S2 (rhG0S2) in (B) mice soleus and EDL (n = 7) and (C) human vastus lateralis muscle (n = 5). (D) TAGH activity was measured in absence (control) or presence of recombinant human G0S2 (rhG0S2), CGI-58 (rhCGI-58), or both (rhG0S2+rhCGI-58) in COS7 cell extracts overexpressing human ATGL (n = 4). *p < 0.05 versus control.