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. 2016 Apr 22;5(7):527–537. doi: 10.1016/j.molmet.2016.04.004

Figure 6.

Figure 6

G0S2 knockdown reduces glucose metabolism and enhances mitochondrial function. (A) Glucose oxidation and (B) glycogen synthesis were measured in control myotubes (shNT) and myotubes knocked down for G0S2 (shG0S2) using [U–14C] glucose. (C) PDK4 gene expression was measured in control myotubes (shNT) and myotubes knocked down for G0S2 (shG0S2) in absence or presence of a selective PPARδ antagonist GSK0660 500 nM PCG1α gene expression (D), mitochondrial mass (E), and mitochondrial membrane potential (F) were measured in control myotubes (shNT) and myotubes knocked down for G0S2 (shG0S2) (n = 9). *p < 0.05, **p < 0.01, ***p < 0.001 versus shNT.